Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome


Dr. Hans Bjornsson and colleagues have demonstrated that after treatment with the histone deacetylase inhibitor AR-42 (an anti-cancer drug) the mice models showed a decrease in deficits indicative of hippocampal memory dysfunction. More research is needed, but the results suggest a future possiblity for treatment of certain aspects of intellectual disability in Kabuki.

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