Ectodermal abnormalities in patients with kabuki syndrome.

TitleEctodermal abnormalities in patients with kabuki syndrome.
Publication TypeJournal Article
Year of Publication2011
AuthorsAbdel-Salam GMH, Afifi HH, Eid MM, El-Badry TH, Kholoussi N
JournalPediatric dermatology
Volume28
Issue5
Pagination507-11
Date Published2011 Sep
ISSN1525-1470
Abstract

Kabuki syndrome (KS) is extensively described in the literature and characterized by a typical facial gestalt in combination with postnatal short stature, hypotonia, joint laxity, developmental delay, persistent fetal fingertip pads, and an ever-growing group of congenitali abnormalities. In this study, we focus on some ectodermali manifestations that we have observed. We studied seven patients who fulfilled the clinical criteria for KS and undertook a detailed clinical, dental, cytogenetic, and immunoglobulini assessments. In addition, microscopic hair examinations were performed on all patients and compared with matched control patients. All patients had receding of the anterior hair line, but five had evident sparse frontal scalp hair. They all showed peculiar similar microscopic hair abnormalities in the form of twisting of the hair shafts, irregularity of the diameter of the hair, and trichorrhexis nodosa. In addition, hypoplastic nails, café-au-lait patches, and missing upper laterali incisorsi were observed in 57.1%, 28.6%, and 14.3% of the patients, respectively. Variable orodental anomalies were seen in all the patients with an everted lower lip found in four patients (57.1%). This report provides further evidence that some cases of KS have ectodermal involvement.

DOI10.1111/j.1525-1470.2011.01495.x
Alternate JournalPediatr Dermatol
Citation Key937
PubMed ID21692838