The H3K27me3 demethylase UTX in normal development and disease.

TitleThe H3K27me3 demethylase UTX in normal development and disease.
Publication TypeJournal Article
Year of Publication2014
AuthorsVan der Meulen J, Speleman F, Van Vlierberghe P
JournalEpigenetics
Volume9
Issue5
Date Published2014 Feb 21
ISSN1559-2308
Abstract

In 2007, the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) was identified as a histone demethylase that specifically targets di- and tri-methyl groups on lysine 27 of histone H3 (H3K27me2/3). Since then, UTX has been proven essential during normal development, as it is critically required for correct reprogramming, embryonic development and tissue-specific differentiation. UTX is a member of the MLL2 H3K4 methyltransferase complex and its catalytic activity has been linked to regulation of HOX and RB transcriptional networks. In addition, an H3K27me2/3 demethylase independent function for UTX was uncovered in promoting general chromatin remodeling in concert with the BRG1-containing SWI/SNF remodeling complex. Constitutional inactivation of UTX causes a specific hereditary disorder called the Kabuki syndrome, whereas somatic loss of UTX has been reported in a variety of human cancers. Here, we compile the breakthrough discoveries made from the first disclosure of UTX as a histone demethylase till the identification of disease-related UTX mutations and specific UTX inhibitors.

Alternate JournalEpigenetics
Citation Key1426
PubMed ID24561908