Patient with Kabuki syndrome and acute leukemia.

TitlePatient with Kabuki syndrome and acute leukemia.
Publication TypeJournal Article
Year of Publication2003
AuthorsScherer S, Theile U, Beyer V, Ferrari R, Kreck C, Rister M
JournalAmerican journal of medical genetics. Part A
Date Published2003 Sep 15

Kabuki syndrome is a multiple congenitali anomalyi/mental retardation syndrome which often involves recurrent infections. There is cumulative evidence of an immunodeficiency in Kabuki patients. We report a 2-year-old girl with typical Kabuki syndrome, who developed acute lymphocytic leukemia. The patient showed low levels of immunoglobulins G and A and a history of recurrent infections, that might indicate an immunodeficiency leading to an increased susceptibility to cancer. The girl was treated according to BFM protocols adapted to the patient's impaired cardiac situation and severe underweight. She achieved continual complete remission. Classical and molecular cytogenetic analyzes did not detect any abnormality.

Alternate JournalAm. J. Med. Genet. A
Citation Key12949977